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Bacillus cereus (the most widely used and the most studied Bacillus cereus strain for human use) is a microbe from the human intestinal tract that can be found in some tissues such as the pancreas, skin, intestine, heart, and the liver, and in a few other species. However, the Bacillus cereus strain found in the human body has been considered the best candidate for use in clinical research for a long time (1–4). To determine in what circumstances Bacillus cereus can be used clinically, it is first necessary to evaluate the biological effects that will be observed in patients. A clinical trial with Bacillus cereus for the treatment of gastric cancer is one of the most promising new clinical trials of aging-related pathologies.
The goal of a gastric cancer clinical trial with Bacillus cereus is to examine the molecular mechanisms by which the Bacillus cereus strain causes the cellular stressors and cells to grow out of control. We would also like to show that these cellular stressors and cells can be cleared through normal or immunological treatments, and if they are cleared, that they can be reintegrated back into the human body after cancer has been removed. By doing this, they will make the treatment more effective and it will be possible to reduce the side effects (pain, nausea) of the current treatments, which are also more toxic to healthy cells, for example.
A study on human gastric cancer cells was initiated in 1993 in an animal research center (5). Since then, many studies have been conducted using B. cereus and Bacillus cereus in the human gastric lining of the stomach (7–9). In this study, researchers compared the cells in the gastric lining against cell lines that can form all the cell lines that are used for human use (10–13). The researchers observed that the cells in the stomach lining could grow out of their own, unaltered cellular fate and the cancer cells were removed after 1 week. The researchers observed that the cells had the ability to express their own self-repair capabilities and were able to express genes associated with apoptotic, or programmed death, which are important factors for the removal of damaged cells and their recycling. Furthermore, the researchers found that the cells in the stomach lining grew out of control, they had no self-repair